Continuous Subcutaneous Insulin Infusion: Pump Settings and Safety for Daily Use

January 14 Tiffany Ravenshaw 0 Comments

When you first start using an insulin pump, it can feel overwhelming. You’re not just switching from injections-you’re taking on a new daily responsibility that affects every meal, every workout, every night’s sleep. But for many people with type 1 diabetes, or those with unstable type 2 diabetes who need tight control, insulin pump therapy changes everything. It gives you flexibility, precision, and often better blood sugar results. But only if you get the settings right-and know what to do when things go wrong.

How Insulin Pumps Actually Work

Insulin pumps don’t replace your pancreas. They deliver rapid-acting insulin-like Humalog or Novolog-through a tiny tube under your skin. There’s no long-acting insulin involved. Instead, the pump gives you two kinds of insulin doses: a steady background trickle called the basal rate, and bigger bursts called boluses for food or high blood sugar.

Basal rates are programmed to change throughout the day. Your body needs more insulin in the early morning (dawn phenomenon) and less overnight. Most pumps let you set up to eight different basal profiles. You might have one for weekdays, another for weekends, and a third for when you’re sick or exercising. The total basal insulin usually makes up 40-50% of your daily insulin dose, spread out hour by hour.

Boluses are trickier. You don’t just press a button and forget it. You need to count carbs accurately. If you eat a pizza, you might need an extended bolus-a slow delivery over 2-4 hours-because fat slows digestion. For a bowl of rice or fruit, a standard bolus works fine. Some pumps even let you split the bolus into two parts: immediate + extended. That’s called a dual-wave bolus.

The Three Core Settings You Must Get Right

There are three numbers that make or break your pump therapy: basal rate, insulin-to-carbohydrate ratio (ICR), and insulin sensitivity factor (ISF). Mess up any one of these, and your blood sugar will swing wildly.

  • Basal rate: This is your background insulin. Test it by fasting for 8-12 hours without food or correction boluses. If your blood sugar drops more than 1 mmol/L, your basal is too high. If it rises, it’s too low. Do this test at different times of day-morning, afternoon, night.
  • Insulin-to-carb ratio (ICR): How much insulin you need per gram of carbs. A common starting point is 1 unit per 10-15g of carbs, but it’s personal. If you’re eating 40g of carbs and your blood sugar stays high after a bolus, your ratio might be 1:12 instead of 1:15. Track it for a week and adjust.
  • Insulin sensitivity factor (ISF): How much 1 unit of insulin lowers your blood sugar. Most people see a drop of 2-4 mmol/L per unit. If your blood sugar is 12 mmol/L and you want it at 6 mmol/L, you need about 2 units-but only if your ISF is 3 mmol/L per unit. Test it by correcting a high reading when you haven’t eaten in 4 hours.

Don’t guess these numbers. Use your pump’s download history. Your diabetes educator can pull your data and show you patterns. If your blood sugar spikes every morning at 3 a.m., your basal is too low. If you crash after lunch, your ICR might be too high.

Infusion Sets and Site Care

Your pump doesn’t work if the insulin can’t get into your body. The infusion set-a tiny plastic cannula under your skin-needs to be changed every 2-3 days. Leaving it in longer increases infection risk and causes insulin absorption problems.

Rotate your sites: abdomen, thighs, upper arms. Avoid scar tissue or areas that feel lumpy-that’s lipohypertrophy. Studies show 27% of new pump users develop it because they reuse the same spots. If you notice your insulin isn’t working like it used to, check your site. A red, swollen, or painful spot? Change it immediately.

Always prime the tubing before inserting a new set. Air bubbles mean you’re not getting the full dose. And never skip the 10-unit test bolus after insertion. It confirms flow and catches blockages early.

Close-up of an infusion set with floating insulin and carb icons.

Safety First: What Happens When Things Go Wrong

The biggest fear with pumps? Diabetic ketoacidosis (DKA). It can happen in as little as 2-4 hours if your infusion set kinks, your tubing disconnects, or your reservoir runs dry. You won’t always feel it coming. That’s why checking your blood sugar every 2-4 hours is non-negotiable.

If your blood sugar stays above 13 mmol/L for two readings in a row, check your pump. Is the tubing kinked? Is the reservoir empty? Is the site red or swollen? If everything looks fine but your sugar won’t drop, give yourself a correction shot with a pen. Then call your diabetes team. Never wait.

For hypoglycemia, remove the pump if your blood sugar drops below 4 mmol/L and stays low. The pump will keep delivering insulin-even if you’re asleep. That’s why many newer pumps have predictive low-glucose suspend features. They stop insulin delivery for 30-120 minutes if your glucose is dropping fast. But even these aren’t foolproof. You still need to carry fast-acting glucose tablets.

Special Situations: Surgery, Pregnancy, and Illness

If you’re having surgery, your pump settings change. For minor procedures where you’ll eat within a few hours, your pump can stay on-if your site is accessible, your insulin reservoir is full, and your glucose is between 4-12 mmol/L. For major surgery? The pump comes off. You’ll get IV insulin until you’re eating again.

After giving birth, your insulin needs drop fast. Many women need to reduce their basal rate by 10-20% within hours. If you’re breastfeeding, you might need even less. Track your sugars closely. Your body’s changing fast.

When you’re sick, your insulin needs go up-even if you’re not eating. Your basal rate might need a 20-50% increase. Check ketones every 4 hours. If you have moderate to large ketones, call your doctor. Don’t wait.

Technology Is Getting Smarter-But You Still Have to Be Involved

The latest pumps, like the Tandem Mobi or Medtronic MiniMed 670G, can adjust basal insulin automatically. They’re called hybrid closed-loop systems. They use your CGM to tweak insulin delivery overnight and between meals. But they still need you to tell them when you’re eating. You still have to count carbs. You still have to check your blood sugar.

Dr. Anne Peters says it best: “CSII is not an artificial pancreas.” It’s a tool. A powerful one. But it doesn’t think for you. The pump can’t tell if you ate a muffin or a whole cake. It can’t know if you’re stressed or running a fever. That’s your job.

And yes, tech fails. About 45% of users report a pump malfunction in the first year. Batteries die. Tubing cracks. Algorithms glitch. That’s why every pump user needs a backup plan: extra infusion sets, insulin pens, syringes, glucagon, and glucose tabs. Keep them in your bag, your car, your desk drawer. Always.

Person in bed alarmed by pump alert, emergency supplies nearby.

Training and Realistic Expectations

Most people think they’ll master the pump in a week. Reality? It takes 3-6 months to feel confident. You’ll make mistakes. You’ll have high blood sugars after meals. You’ll forget to bolus. You’ll get frustrated.

Good training matters. The Association of Diabetes Care & Education Specialists recommends at least 15 hours of education before you start. That includes: how to insert a set, how to program a bolus, how to troubleshoot alarms, and how to respond to DKA. Don’t rush it. Start your pump on a Monday, not a Friday. That way, you have support through the week.

After four weeks, you’ll have a follow-up with your diabetes team. They’ll download your pump data and look at your patterns. That’s when real adjustments happen. Don’t skip it.

Who Should Use a Pump?

Not everyone needs one. The American Diabetes Association says you’re a good candidate if:

  • You have type 1 diabetes and want tighter control
  • You’re willing to check your blood sugar at least four times a day
  • You can count carbs consistently
  • You’re not afraid of technology
  • You don’t have severe hypoglycemia unawareness without a CGM

If you’re not ready to manage this level of detail, injections might be better. There’s no shame in that. The goal isn’t to use the fanciest tech-it’s to stay healthy.

What Comes Next?

The future of insulin pumps is exciting. Bi-hormonal pumps that deliver both insulin and glucagon are in trials. Interoperable systems let you mix and match pumps with any CGM. The smallest pump yet, the Tandem Mobi, is designed for kids. But none of this matters if you don’t understand the basics.

Insulin pump therapy isn’t magic. It’s a daily commitment. It requires attention, patience, and a willingness to learn. But for those who stick with it, the payoff is real: fewer lows, more freedom, and better long-term health.

Start with the numbers. Master the basics. Keep backups. And never stop asking questions.

Tiffany Ravenshaw

Tiffany Ravenshaw (Author)

I am a clinical pharmacist specializing in pharmacotherapy and medication safety. I collaborate with physicians to optimize treatment plans and lead patient education sessions. I also enjoy writing about therapeutics and public health with a focus on evidence-based supplement use.